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iSAEC publications:

(ordered by year of publication)

Genome-wide association study of serious blistering skin rash caused by drugs, Shen Y, Nicoletti P et al., Pharmacogenomics J. 2011.

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Daly, A.K., Donaldson, P.T. et al. Nature Genetics. 2009.

Non-iSAEC reference articles:

(ordered by year of publication)

Using electronic health records to drive discovery in disease genomics. Isaac S. Kohane. Nature Reviews, June 2011, Volume 12

Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan. Pei Chen, Juei-Jueng Lin, Chin-Song Lu, Cheung-Ter Ong, et al. The New England Journal of Medicine, March 2011,

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans. Mark McCormack, Ana Alfirevic, Stephane Bourgeois, John J. Farrell, et al. The New England Journal of Medicine, March 2011,

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. George F Mells, James A B Floyd, Katherine I Morley, Heather J Cordell, et al. Nature Genetics, March 2011

The Spectrum of Nimesulide-Induced-Hepatotoxicity. An Overview. Fernando Bessone, Luis Colombato, Eduardo Fassio, Maria Virginia Reggiardo, Julio Vorobioff and Hugo Tanno. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, December 2010,

Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis. Sicard, Zai, Tiwari et al. Future Medicine Ltd. Nov 2010.

ALDEN, an Algorithm for Assessment of Drug Causality in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Comparison With Case–Control Analysis. B Sassolas, C Haddad, M Mockenhaupt, A Dunant, Y Liss, K Bork, UF Haustein, D Vieluf, JC Roujeau and H Le Louet for the RegiSCAR Study Group Nature Publishing Group. July 2010.

Prepublication Data Release, Latency, and Genome Commons. Jorge L. Contreras American Association for the Advancement of Science. July 23,2010.

Genome-wide association studies in pharmacogenomics. Ann K. Daly Nature Genetics. April, 2010.

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. Colin J D Ross, Hagit Katzov-Eckert, et al. Nature Genetics. 2009.

Pharmacogenomic approaches in clinical studies to identify biomarkers of safety and efficacy. M.E. Burczynski. Toxicology Letters.

The Changing Face of Biobanks. Jeanene Swanson. GenomeWeb. July/August 2009

HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Kaniwa, N., Saito, Y., Aihara, M., Matsunaga, K., et al. Pharmacogenomics. 2008,

SLCO1B1 Variants and Statin-Induced Myopathy - A Genomewide Study. The SEARCH Collaborative Group. The New England Journal of Medicine. 2008 Aug 21.

SKDM human leukocyte antigen (HLA) tool: A comprehensive HLA and disease associations analysis software. Stathis Kanterakis, Eleni Magira, Kenneth D. Rosenman, Milton Rossman, Keyur Talsania, Dimitri S. Monos. ASHI: American Society for Histocompatibility & Immunogenetics. Human Immunology

Mapping the genetic architecture of gene expression in human liver, Schadt, E.E., C. Molony et al., PLoS Biol, 2008. 6(5): p. e107.

A European Study of HLA-B in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Related to Five High-risk Drugs. Lonjou, C., Borot, N., et. al. Pharmacogenetics and Genomics

Case-control study of the association between select HLA genes and anti-erythropoietin antibody-positive pure red-cell aplasia. Figal, B., Ricci, D., et al. Pharmacogenomics

The innovative use of a large-scale industry biomedical consortium to research the genetic basis of drug induced serious adverse events. Holden, A. Drug Discovery Today: Technologies. 2007 Nov.

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM. Nat Rev Drug Discov. 2007 Nov;

Tacrine-induced liver damage: an analysis of 19 candidate genes. Ana Alfirevic, Tracy Mills, Daniel Carr, Bryan J. Barratt, Ansar Jawaid, James Sherwood, John C. Smith, Jonathan Tugwood, Ruben Hartkoorn, Andrew Owen, Kevin B. Park and Munir Pirmohame. Pharmacogenetics and Genomics 2007, 17:1091–1100.

Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. Daniel F. Carr, Ana Alfirevic, Jonathan D. Tugwood, Bryan J. Barratt, James Sherwood, John Smith, Munir Pirmohamed and B. Kevin Park. Pharmacogenetics and Genomics 2007, 17:961–972.

Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. M. Pirohamed, J. Arbuckle, C. Bowman, M. Brunner, D. Burns, O. Delrieu, L. Dix, J. Twomey, R. Stern. Pharmacogenomics 2007.

Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review. K. Pachkoria, M. I. Lucena, M. Molokhia, R. Cueto, A. S. Carballo, A. Carvajal and R. J. Andrade. Current Drug Safety, 2007,

A marker for Stevens-Johnson syndrome ...: ethnicity matters. Lonjou C, Thomas L, Borot N, Ledger N, de Toma C, LeLouet H, Graf E, Schumacher M, Hovnanian A, Mockenhaupt M, Roujeau JC; RegiSCAR Group. Pharmacogenomics J. 2006 Jul-Aug; Epub 2006 Jan 17. PMID:

National surveillance of emergency department visits for outpatient adverse drug events. Budnitz DS, Pollock DA, Weidenbach KN, Mendelsohn AB, Schroeder TJ, Annest JL. JAMA. 2006 Oct 18;

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM. BMJ. 2004 Jul

Cytochrome P450 2E1 Genotype and the Susceptibility to Antituberculosis Drug–Induced Hepatitis. Huang, Y.S., Chern, H.D., Su, W.J., Wu, J.C., Chang, S.C., Chiang, C.H., Change, F.Y., Lee, S.D., Chang, F.Y., Lee, S.D. Hepatology,

A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. Watanabe, I., Tomita, A., Shimizu, M., Sugawara, M., Yasumo, H., Koishi, R., Takahashi, T., Miyoshi, K., Nakamura, K., Izumi, T., Matsushita, Y., Furukawa, H., Haruyama, H., Koga, T. Clinical Pharmacology and Therapeutics, May, 2003.

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women's Health Initiative Investigators. JAMA. 2002 Jul 17;

Genetic Susceptibility to Adverse Drug Reactions. Munir Pirmohamed and B. Kevin Park. TRENDS in Pharmacological Sciences. June 2001;

Age adjustment using the 2000 projected U.S. population. Klein RJ, Schoenborn CA.Healthy People 2010 Stat Notes. 2001 Jan;

Pharmacogenetics and adverse drug reactions. Meyer UA. Lancet. Review. PMID: 11089838

Adverse Drug Events: The Magnitude of Health Risk is Uncertain because of Limited Incidence Data. GAO, January 2000.

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. Lazarou J, Pomeranz BH, Corey PN. JAMA.