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HLA-DRB1*16:01-DQB1*05:02 is a novel genetic risk factor for flupirtine-induced liver injury, Paola Nicolettia, Anneke N. Werkf, Ashley Sawlec, et al, Pharmacogenetics and Genomics, February 1, 2016.
Clinical features and HLA association of 5-Aminosalicylate (5-ASA) induced nephrotoxicity in inflammatory bowel disease, Graham A Heap, Kenji So, Mike Weedon, et al, Journal of Crohn's and Colitis, November 29, 2015.
Antipsychotic medications and extremeweight gain in two health systems, David Arterburna, G. Craig Woodc, Mary Kay Theisa, et al, Obesity Research & Clinical Practice, August 2015.
Phenotype standardization for drug-induced kidney disease, Ravindra L. Mehta, Linda Awdishu, Andrew Davenport, et al, Kidney International, April 2015.
The International Serious Adverse Events Consortium, Arthur L. Holden, Jorge L. Contreras, Sally John and Matthew R. Nelson, NATURE REVIEWS | DRUG DISCOVERY, VOLUME 13 | NOVEMBER 2014.
HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants, Graham A Heap, Michael N Weedon, Claire M Bewshea1, et al, Nature Genetics, September 2014.
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles, Jacqueline I. Goldstein, L. Fredrik Jarskog, Chris Hilliard, et al, Nature Communications, September 2014.
Testing the Hapten Concept for Drug-Induced Liver Injury, Jacqueline I. Goldstein, Elaine T. Lim, Hailiang Huang, et. al., Annual Meeting of the American Society of Human Genetics, Boston, October 2013.
The International Serious Adverse Events Consortium's data sharing model, Contreras JL, Floratos A, Holden AL., Nat Biotechnol, , Jan 9 2013.
Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs, Urban TJ, Shen Y, Stolz A, Chalasani N et al., Pharmacogenetics and Genomics, September 2012.
The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes, Elijah R. Behr, Craig January, Eric Schulze-Bahr, Andrew A. Grace et al., European Heart Journal, July 2012.
The Phenotype Standardization Project: Improving Pharmacogenetic Studies of Serious Adverse Drug Reactions, M Pirmohamed, GP Aithal, E Behr, A Daly et al., Clin Pharmacol Ther., , 2011.
Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury, M Pirmohamed, PS Friedmann, M Molokhia, YK Loke et al.,Clin Pharmacol Ther., , 2011.
Case Definition and Phenotype Standardization in Drug-Induced Liver Injury, GP Aithal, PB Watkins, RJ Andrade, D Larrey et al., Clin Pharmacol Ther., , 2011.
Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles, M. Isabel Lucena, Mariam Molokhia, Yufeng Shen, Thomas J. Urban et al., Gastroenterology. 2011.
Genome-wide association study of serious blistering skin rash caused by drugs, Shen Y, Nicoletti P et al., Pharmacogenomics J. 2011.
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Daly, A.K., Donaldson, P.T. et al. Nature Genetics. 2009.
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Major histocompatibility complex class II polymorphisms are associated with the development of anti-resorptive agent-induced osteonecrosis of the jaw.Stockmann P, Nkenke E, Englbrecht M, Schlittenbauer T, et al. Science Direct, Jan 2013
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Clinical practice. Antibiotic allergy.Rebecca S. Gruchalla and Munir Pirmohamed The NEW ENGLAND JOURNAL of MEDICINE, March 2012
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SLCO1B1 Variants and Statin-Induced Myopathy - A Genomewide Study. The SEARCH Collaborative Group. The New England Journal of Medicine. 2008 Aug 21.
SKDM human leukocyte antigen (HLA) tool: A comprehensive HLA and disease associations analysis software. Stathis Kanterakis, Eleni Magira, Kenneth D. Rosenman, Milton Rossman, Keyur Talsania, Dimitri S. Monos. ASHI: American Society for Histocompatibility & Immunogenetics. Human Immunology
Mapping the genetic architecture of gene expression in human liver, Schadt, E.E., C. Molony et al., PLoS Biol, 2008.
A European Study of HLA-B in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Related to Five High-risk Drugs. Lonjou, C., Borot, N., et. al. Pharmacogenetics and Genomics
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Tacrine-induced liver damage: an analysis of 19 candidate genes. Ana Alfirevic, Tracy Mills, Daniel Carr, Bryan J. Barratt, Ansar Jawaid, James Sherwood, John C. Smith, Jonathan Tugwood, Ruben Hartkoorn, Andrew Owen, Kevin B. Park and Munir Pirmohame. Pharmacogenetics and Genomics 2007,
Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. Daniel F. Carr, Ana Alfirevic, Jonathan D. Tugwood, Bryan J. Barratt, James Sherwood, John Smith, Munir Pirmohamed and B. Kevin Park. Pharmacogenetics and Genomics
Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. M. Pirohamed, J. Arbuckle, C. Bowman, M. Brunner, D. Burns, O. Delrieu, L. Dix, J. Twomey, R. Stern. Pharmacogenomics 2007.
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Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM. BMJ. 2004 Jul
Cytochrome P450 2E1 Genotype and the Susceptibility to Antituberculosis Drug–Induced Hepatitis. Huang, Y.S., Chern, H.D., Su, W.J., Wu, J.C., Chang, S.C., Chiang, C.H., Change, F.Y., Lee, S.D., Chang, F.Y., Lee, S.D. Hepatology,
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. Watanabe, I., Tomita, A., Shimizu, M., Sugawara, M., Yasumo, H., Koishi, R., Takahashi, T., Miyoshi, K., Nakamura, K., Izumi, T., Matsushita, Y., Furukawa, H., Haruyama, H., Koga, T. Clinical Pharmacology and Therapeutics, May, 2003.
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women's Health Initiative Investigators. JAMA. 2002 Jul 17;
Genetic Susceptibility to Adverse Drug Reactions. Munir Pirmohamed and B. Kevin Park. TRENDS in Pharmacological Sciences. June 2001;
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Pharmacogenetics and adverse drug reactions. Meyer UA. Lancet. Review. PMID:
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